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Thread: Your worst 23andme findings1763 days old

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    Molecular Biologist Jonny's Avatar
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    Default Your worst 23andme findings

    So some of you must have some real horror stories about genes you discovered you had which can lead to various illnesses?

    I found out that I have a ~43% (7% for average person) chance of getting diagnosed with Alzheimer's between ages 50-79. This is because I am one of the 1.7% of people who have two copies of the APOE ε4 variant (whatever that is lol). But the 23andme page for this also said, "Most people who develop Alzheimer's are diagnosed after age 80," so I am pretty buggered.

    I am only in my mid 20s now so it is a few decades away yet and I have plenty of time to save for my trip to Dignitas.

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    I have nothing very bad, increased risk for prostate cancer and age related macular degeneration. My son-in-law carries one mutation of Factor XI Deficiency. It sounds bad, but I dont know if one mutation is a risk.
    Last edited by Lemminkäinen; 2012-05-29 at 19:32.
    Blog: http://terheninenmaa.blogspot.fi/, with essence "Believe me, or I'll nuke you".

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    Oh I forgot to mention that I also have:
    "two copies of Delta32 version of CCR5"
    which means I am practically immune to HIV/AIDS.

    Swings and roundabouts.

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    Molecular Biologist ~Elizabeth~'s Avatar
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    My 23andme predicted me to be taller than average.
    I'm actually shorter than average, only five feet tall.

    As for the medical reports, nothing bad. I have good genes.

    edit: I recall reading something about restless leg syndrome and venous thrombosis and being a "sprinter".
    Last edited by ~Elizabeth~; 2012-05-29 at 19:34.

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    Actually I have also a very long list decreased risks and a short list increased risks, but as I wrote some risks have to own to be normal.
    Blog: http://terheninenmaa.blogspot.fi/, with essence "Believe me, or I'll nuke you".

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    Quote Originally Posted by ~Elizabeth~ View Post
    My 23andme predicted me to be taller than average.
    I'm actually shorter than average, only five feet tall.

    As for the medical reports, nothing bad. I have good genes.
    Do you ever worry that there could have been a mix up at the lab?

    I have red hair but have none of the mutations that can cause this that are listed on SNPedia

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    I noticed that I was bugged by things, like having a 9.3% chance of Age Related Macular Degeneration without considering that the average is 7% and i'm certainly not too far away from that. Oooh...I still *might get that. Either way can't do anything about it. *Shrugs. The only thing I am concerned about now, even though my score only deviates from the average by very little is A-Fib. I'm a very fit person. I'm 5'0, 110. But sometimes I feel breathless while working out. That either means i'm working out too much, not hydrating properly, or I just can't work out as much as other people. Hasn't happened in a while now though. Then again, I might simply be seeing non-existent symptoms of A-Fib in my daily life. Which only shows the dangers of diagnosing yourself based on your results. But knowing these kinds of things are beneficial, nonetheless. But I do feel silly for being over worried about my results.

    I'm also decreased for Obesity(I have a higher tendency to not overeat), Schizophrenia, Breast Cancer, Psoriasis, etc etc...Good stuff. And i'm Variant Absent for all of the Carrier Statuses. Restless Leg Syndome is another one i'm at a higher risks for, by like 1%...Watch out people, I might trip over myself in my sleep and die..
    Last edited by modernsappho; 2012-05-29 at 19:48.
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    My alcohol dependence risk is increased, but it cannot be true, because I have never used much alcohol, and even dont like it.
    Last edited by Lemminkäinen; 2012-05-29 at 19:40.
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    Quote Originally Posted by Jonny View Post
    Do you ever worry that there could have been a mix up at the lab?

    I have red hair but have none of the mutations that can cause this that are listed on SNPedia

    Yeah, I thought there was maybe a mix-up, but 23andme got my mtDNA correct, I'm H1c, so I think it's mine. Though oddly, or not so oddly, I have absolutely NO proven paper-trail connection to a single one of my 793 Relative Finder matches. (edit: only about 1/3 of the 793 are sharing with me)

    I'm 1/4 Southern (North Carolina) but I have only a handful of Southern matches. I have no known New England or Canadian ancestry but I have more matches from there. I also have no known Finnish ancestry and I have matches from Finland.

    I also match a few people from Italy and Greece but I have no known ancestry from there either.


    edit: and I don't have pure red hair but I have reddish tones. It depends on how much sun I get. I'm a blondish-reddish light brown. Neither of my parents are redheads but my mother's father was a redhead (strawberry blond) before he went prematurely gray, I was told. My mom was a redhead as a baby but her hair turned black/dark brown (that's what she said she was told).


    My FTDNA FGS/FMS is H1c but according to phylotree's build 14 I am a new subclade: H1c12
    Last edited by ~Elizabeth~; 2012-05-29 at 19:59.

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    Quote Originally Posted by ~Elizabeth~ View Post
    Yeah, I thought there was maybe a mix-up, but 23andme got my mtDNA correct, I'm H1c, so I think it's mine. Though oddly, or not so oddly, I have absolutely NO proven paper-trail connection to a single one of my 793 Relative Finder matches.

    I'm 1/4 Southern (North Carolina) but I have only a handful of Southern matches. I have no known New England or Canadian ancestry but I have more matches from there. I also have no known Finnish ancestry and I have matches from Finland.

    I also match a few people from Italy and Greece but I have no known ancestry from there either.
    I can't find any link to any of the people on my relative finder either. None of the surnames in my family tree from roughly the last 200 years showed up in any of the searches I did.

    I think they are going to build in Gedcom soon, which has to be useful.

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