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Thread: How Reliable Are Home DNA Ancestry Tests? Investigation Uses Triplets to Find Out157 days old

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    Default How Reliable Are Home DNA Ancestry Tests? Investigation Uses Triplets to Find Out

    I had my suspicions about DNA ancestry sites since their reference populations are limited and many are basically secondary window sites to 23andme.com. Here are some investigations done by journalists that give interesting results.


    https://www.insideedition.com/invest...ts-to-find-out


    How Reliable Are Home DNA Ancestry Tests? Investigation Uses Triplets to Find Out

    INVESTIGATIVE 3:16 PM PST, February 21, 2017 - Inside Edition



    Millions of people are purchasing home DNA kits like 23andMe, Family Tree DNA, and Ancestry DNA, to unlock the secrets to their ancestry, but are the results always 100 percent reliable?

    Read: How Accurate Are Home DNA Ancestry Kits? Investigation Uses Triplets to Put Companies to the Test

    To find out, Inside Edition enlisted the help of two sets of indistinguishable triplets and a set of indentical quadruplets to investigate the accuracy of the at-home tests.

    One of the triplets, Erica McGraw, is the daughter-in-law of TV's Dr. Phil McGraw. Her husband, Jay, is the executive producer of the television program The Doctors.


    Erica and her two sisters, Nicole and Jaclyn, used one of the most popular tests, "23 and Me." To complete it, all they had to do was spit in a cup and ship off their samples.

    Another set of triplets taking part in Inside Edition's experiment were the Maynard sisters, who were once on American Idol. They used a test kit from Family Tree DNA, and had to swab the inside of their mouths to complete the test.

    Our third set of identical triplets were from New Jersey and used a kit from Ancestry DNA.

    Also tested were a rare set of identical quadruplets, as the singing Pyfrom Quads, of California, took the test from 23andMe as well.

    “Their ancestry should be absolutely identical,” DNA expert Dr. David Ku, of Universal Genetics, told Inside Edition.

    Inside Edition’s Chief Investigative Correspondent Lisa Guerrero revealed the results to Erica McGraw and her sisters on the set of the TV program The Doctors. She was joined by the show’s host, Dr. Travis Stork.

    The sisters were all 99 percent European but the test from 23andMe also showed some surprising differences.

    Nicole was 11 percent French and German but Erica was 22.3 percent. Their sister Jaclyn was in the middle at 18 percent.

    "I'm surprised," Nicole said. "I’m surprised because we came from the same egg and DNA. How are our ancestries different?"

    Guerrero then met with the Maynard triplets and revealed the results for their “Family Tree DNA” tests. It showed they all had British Isles ancestry but the amount was different.

    Erin Maynard was 59 percent, Mandy was 66 percent and Melissa was 70 percent.

    The tests also showed that Mandy had six percent Scandinavian ancestry but her identical sisters showed none.

    Read: FakeABaby.Com Provides Positive Pregnancy Tests and Sonograms, Some Use It to Dupe Their Lovers

    The sisters were confused and disappointed with the results.

    Guerrero asked them, “Is that disappointing?”

    Erin Maynard responded, “Very.”

    But not everyone was disheartened by the results.

    The Ancestry DNA test results for the New Jersey triplets were almost identical. It revealed that their roots are largely from Great Britain, 45%-47% and their Italian and Greek ancestry was exact at 25%.

    As for the Pyfrom Quads, their results were also almost identical and did not have the variations seen in other sets of our triplets.

    Their test from “23andMe” showed each were 49 percent European and 46 percent West African.

    “What’s the take away from this?” Guerrero asked Dr. Stork.

    "I think the answer here is that we've come so far in terms of genetic testing, but you can't just spit in a cup and have every single answer that you are looking for," Dr. Stork said following the test results.

    Since the test, Family Tree DNA told Inside Edition they have improved their algorithm and will implement a new method in the next few weeks.

    A spokesperson for 23andMe says their results are based on a sliding confidence scale, ranging from 50-90 percent. The higher the confidence level chosen, the less specific the result can be as to the region or country of the person’s ancestry.

    http://www.cracked.com/personal-expe...companies.html

    Inside The Shady World Of DNA Testing Companies


    Evan V. Symon
    ·
    December 04, 2017

    Should you drunkenly celebrate St. Patrick's Day or Oktoberfest? Can you brag about your ancestors having first-class seats on the Mayflower? Do you need to feel extra, extra bad about slavery? All these questions and more can be answered by sending a vial of your spit off to a company like Ancestry.com, 23andMe, or Living DNA ... in theory. But the reality of those businesses is a lot less science, and a lot more hustle. We talked with Morgan, who works for one of the major ancestry testing companies. He had some interesting things to say ...

    6
    The Tests Aren't As Accurate As They're Claimed To Be

    DNA is one of the most aggressively scientific acronyms in the English language. Look at this test results page!




    But when Inside Edition had a set of triplets send their spit in to Ancestry.com and 23andMe, they got wildly different results from both services. Neither gave each triplet the same ancestry results -- which, considering they all came from the same womb, is pretty weird.

    "Tests can be a crapshoot. For DNA tests, they use genetic markers, which are little variations in the DNA one or several groups may have, but others do not. The more markers there are, the more accurate the test will be."

    Some companies may use 12, 37, or 67, while others claim to use more than 700,000 different markers. Any of those numbers can sound impressive with the right marketing spin behind them, but the simple fact of the matter is that nobody's method is perfect. "The best we can do is give a certain range based on those markers (or show who they are most similar to), and sometimes we'll move up a percentage point of an ethnic group if it doesn't add up to 100 percent."

    Inside Edition found differences of over 10 percent between the triplets they tested. That is not a small gap. If you were off by 10 percent on a DNA test, you could technically be a mouse. Maybe it's unreasonable to expect perfect accuracy from saliva you mailed to a lab. But a lot of people do anyway, and Morgan winds up dealing with their complaints.

    "At least once a week, we'll get a call from somebody who took two or three other tests and then ours, and complains about how different they are. Usually it's 5-20 percent off, but we got an email from a guy showing how in one test he was 7 percent Irish, Scottish, and Welsh, then on another he was 33 percent, and then on ours 45 percent, and he wanted to know what was wrong with everyone. We wrote to him that each test is different because of the number and types of genetic markers used, which can skew data, but he wrote back and said that we were con men."

    Genetics experts from the University of Texas and the University of North Carolina have gone so far as to say that these companies are preying on people, because they don't truly have the information they need to pinpoint your origins on a map, and that it's not possible to trace unique ancestry that way. As they put it, "That's the beauty of this scam. The companies aren't scamming you. They're not giving you fraudulent information. They are giving you data, real data, and allowing you to scam yourself."

    Even though Morgan works for one of these companies, he doesn't buy into the accuracy of the product. How could he? "We were doing our own internal tests when I started, and I took the same test five times in five weeks, and I got different results each time. One of the lab assistants wasn't upset about it. He told me, 'Look at the range there. That's about where your ancestors are from.' Somebody asked him, 'We promise accurate results. How is it accurate if he got different results each time?' And the lab assistant said, 'If you average them all, you have a good idea, right?'"

    On one hand, these tests are definitely a con. But on the other hand, the customers are as guilty as the companies. People want to know where they come from so they can brag about being 1/64th Cherokee in internet arguments. No one actually wants to spend hours studying genealogy and pay hundreds of dollars for a dozen different, possibly more accurate tests. "If you get a high percentage, it's a safe bet that you have ancestors from there. I'm talking about a 50-60 percent on your test. Anything lower, and take it with a grain of salt."

    5
    They Might Tweak Results To Avoid Pissing People Off

    Morgan admitted to having changed people's results. "We only did this on rare occasions, when we knew they weren't using it as means to harm someone." A lot of this is done under the guise of having the tests line up with what the business already knows of the customer's expectations. It's easier to do that than to deal with an endless parade of clients who are intensely pissed off because they aren't as Dutch as they expected to be.

    "If the results only added up to 99.5 percent, we'd say, 'Let's stick that 0.5 percent under Scandinavian.' Other times, when we ask their family name (for women, their maiden name), and we see what country that last name came from, we'll add it there, because they'll be more proud of that heritage more often than not." As scientific as DNA tests seem, we're still talking about a customer-focused industry. It pays to suck up to the people who pay you.

    "One woman sent the packet out with green shamrocks and a green leprechaun hat on it. She was really proud to be Irish. She even said she was excited to see if she was 100 percent Irish. But the test found no Irish blood. It was half Eastern Europe, then a mix of different places in Germany and Italy, and even Greece." Clearly, this woman's family had either lied to her, been lied to themselves, or she was one of those stealth adoptions that happen every so often. "The consensus was that she would send a huge fit if she was shown not to be Irish at all, so we made her 20 percent Irish and highlighted our disclaimer about results not being accurate." Or they could have put down "100 percent" on St. Patrick's Day and still technically be right.

    Morgan wasn't at all ashamed or guilty about this. And we can't really blame him. If you've ever waited tables, you know how fucking crazy people can get when their expectations are challenged in any way. Now take the anger of someone not booking a reservation they really wanted, and amplify that by someone learning for the very first time that Great Uncle O'Leary's tales about the Emerald Isles were a pack of lies.

    "We actually started it here, because during our first year, a woman found out that all of her parents' stories about her ancestors coming on the Mayflower were lies (She was nearly 100 percent German). [She] came to our physical offices, cracked her way inside, and confronted the staff in person. I wasn't with the company then, but it's still talked about here. They had to call the police because all the security staff in the building couldn't get her out."

    It's not unheard of for genetic tests to be altered. New York crime lab workers have sued the police for forcing them to change or ignore results, and The New York Times found that anything related to DNA, from Ancestry results to crime scenes, can be fabricated easily. North Korea disavows that Kim Jong-Un is a quarter Japanese, despite a lot of evidence to the contrary. So Morgan and his co-workers aren't even close to alone in their little DNA-based white lies.

    4
    It's Really Easy to Mess Up The Tests

    There are a lot of ways to get DNA: blood, semen, bloody semen, etc. But Morgan's company, and most of the industry, prefers to use spit. "We use saliva for our test. You get this vial in a packet we send, and after washing out your mouth with Listerine to kill all germs, you spit." (If it's just chewing tobacco spit, they'll mark you down as "Alabaman" and leave it at that.)

    It sounds simple enough. But people fuck it up all the time, because people fuck everything up all the time. It's our prerogative. "One out of four people we need a new vial for, because something went wrong. We'll often get food in there, or they drink something, then spit and not realize it."

    And yes, sometimes they "fuck up" literally. "Once a man sent us a vial full of semen, and I don't know HOW he could have gotten that part wrong. Our lab assistants were originally going to rule it out immediately because of how cloudy they thought the 'saliva' was, but one of them decided to see anyway. She opened it up to begin testing, but as soon as she saw the viscosity, she dropped it and said, 'That's semen!' One of us had to call him directly and tell him what he did wrong, and to his credit, he did give a mortified apology."

    Another thing that complicates DNA test results: interracial lovemaking. "Sometimes the saliva looks good and we test it, but then the results show something really messed up. We had a few tests where the genetic markers where everywhere, on five continents. It's really rare for that to happen. The percentage points were 10 percent in India, 10 percent in China, 5 percent Native American, 10 percent Sub-Saharan Africa, 20 percent Scandinavia-Norway. You can imagine. I called [some of these customers], I explained what the situation was and went down the results, and what always happened was that they would say yes to half, and no to the other half of the ancestry they knew. When we asked if they knew anyone who fit the other ancestry results, they would say, 'Oh, my husband/wife/fiancee/boyfriend/girlfriend is!'"

    It's not uncommon for tests to take way more than one vial to work. There have been cases of users repeatedly sending in vials, as many as eight times. "It's not unheard of. And I've had more than eight. We had someone who tried 14 times before it finally worked. They had bad teeth, and little tooth bits kept going in the saliva and messing up the results. They weren't big pieces, maybe like grains of sand. But it was enough. By the sixth time it happened, she was known as 'Tooth Girl,' and I would get a message saying, 'Tooth Girl struck again.' She never called once, either. Usually, by the third time, they'll ask what went wrong and how to do it better. Maybe they didn't clean good, or maybe something bled. It happens. But she never asked, and kept sending in vials with tiny bits of teeth."

    Eventually, Tooth Girl's tests worked out and they were able to send her useful information. Morgan and his co-workers would never fuck with someone for having bad teeth. Not when there are so many better reasons ...

    3
    They Will Screw With Racists

    "I only know of two times somebody wanted to be tested for being another ethnicity because they didn't like that ethnicity. Both times, [they were] white people not wanting to believe they had black ancestors." The first of these made an offhand remark that, "'I'm hoping it will show people I'm not black.' And not as a joke. He was serious." The second customer was even less subtle: "He caught himself from saying the N-bomb. He said, 'I want to know if any of my family are ni- black.'"

    Morgan and his colleagues were caught between a rock and a really-want-to-mess-with-racists place. It would've been fun to throw a "10 percent West African" in there, but then they might have a pissed-off, dangerous person at their office, waving a gun. "Since we couldn't do anything to the results (and we wanted to), what we did was add '< 1 percent' to each African category of ethnicity. That way we weren't lying, and they would both be wondering how much under a percentage point was. We always try to round to the nearest number because we sometimes hear about percentage points, but for them, we leave it open to whether it's a one or a zero."

    It's a compromise that's elegant in its passive-aggressive simplicity. And it got a result. "The near-N-bomber wrote to us asking what that meant, and we wrote back that it meant it was under 1 percent. And we were not saying zero. Unless they got another test, that was going to bother them. Maybe they weren't 100 percent Caucasian. I mean, they were, according to the results, but this way it leaves it open, and they'll always be wondering."

    Bravo. Bravissimo!

    2
    They Uncover Hidden Family Secrets

    Genetic ancestry tests have caused a lot of problems, from cops being treated differently when they suddenly learn they're of mixed race to happy marriages ending when a test reveals hidden infidelities. So Morgan gets lots and lots of calls.

    "The number one reason they call us after they get their results back is to contest something that exposed a family secret. Sometimes it was a parent not really being their parent, or an orphan who didn't know their history now finding out that they were half Native American this entire time and needing someone to talk to." Obviously, that kind of news would be shocking for anyone. But sometimes it goes well beyond mere shock.

    "A few new adopted people even called me to say how the test ruined their lives, because it encouraged them to dig or confront their parents. I had a woman who was OK with being adopted, but mortified to know that she had been born in South Carolina, and she threatened to sue us because she found that out. We had to let Legal handle it as soon as 'suing' was said, but I really couldn't believe she was crying over being born in South Carolina."

    DNA testing has apparently been a real nightmare for parents who casually lie to their children. "A man who also found out he was adopted called us to say that he and his parents were now no longer on speaking terms. Everything had been fine until he took the test. His family was 100 percent Scots-Irish, and the tests showed him as 100 percent Eastern European. His family had never told him, and he made it until his 20s before finding out. There had been some big blowout, and he told me, 'Your company ruined my entire life. I don't even know who I am anymore,' and he started crying. We didn't ruin the relationship with his family, but I concede we probably provided the spark for it."

    But for every heartbreaking revelation of lies and infidelity, Morgan has stories like this: "I didn't talk to him, but someone who called us had lost his parents and his brother in an accident, was left with no family, and then decided to do a DNA test. It led him down a rabbit hole of finding out that he had been adopted, and that he had a completely different birth family welcoming him in open arms."

    1
    People Demand They Forge Their Results

    "You would think there would be a lot of racists wanting black ancestry changed, but except for maybe two incidents, it hasn't happened. Most white people who found out that they're part black or part Native American have been quite accepting, if not a little excited. And black people who found out they're part white have been the same way. It's the sub-areas or implied ancestry that make people mad enough to call us." Oddly enough, "most of our calls have been from people wanting to be changed from Italian."

    Usually, such demands are a matter of pride. People want to be able to wave around a sheet of paper that says they've got whatever in their background because it makes them feel fancy. "We had a Jewish man in Canada ask us to make it look like he was from Israel. His results showed him to be from Eastern Europe, and based on his last name, we said it was all but certain his ancestors were from Poland. Judging by his family history, they probably came over around WWII, for reasons you can probably imagine. But no, he said he was Jewish and wanted 'Eastern European' changed to the area Israel is in."

    As you might guess, being Jewish doesn't work that way. There's a big difference between Jewish people who came from European ancestry and someone whose family has been living in the land currently occupied by Israel for thousands of years. "Israel is new ... and by saying he's from there by blood, we'd be saying he was Arab. We have changed things on occasion ... and we played along with him over the phone. 'Sure, we can change your ancestry to being from the near Middle East.' We gave him the option of being more from Egypt, more from Syria, or more Arab. He wasn't what you would call happy that those were his only options, and when operator asked him, 'Would you like to be Arab?' he slammed the phone down."

    It all comes down to pride, and the unfortunate fact that race matters a lot more to most people than they're willing to admit. There are millions of folks out there who'd never argue one race is superior to another, but who'd fight you to the death if you dared to suggest they were German instead of Scottish. "I've had boyfriends wanting to impress girlfriends, somebody who wanted to get into the Knights of Columbus, and I even had someone trying to prove he was part Native American to join a tribe. We won't change for fraudulent reasons, and besides, even if we did, these tests only give an indication. They aren't 100 percent. A man who wanted the results changed to being more Native American told us from the first sentence that he was trying to join a tribe, but no test gave him any Native American blood. Ours didn't either."

    We'd bet our life savings that he still tells girls at parties about his tribe, though.

    Evan V. Symon is an interviewer, interview coordinator, and journalist for the Cracked personal experience team. Have an awesome job/experience you'd like to talk about? Then hit us up at tips@cracked.com today!

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