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Thread: World’s first ever human-monkey hybrid grown in lab in China53 days old

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    Exclamation World’s first ever human-monkey hybrid grown in lab in China

    Scientists have successfully formed a hybrid human-monkey embryo – with the experiment taking place in China to avoid “legal issues”.

    Researchers led by scientist Juan Carlos Izpisúa spliced together the genes to grow a monkey with human cells.

    It is said the creature could have grown and been born, but scientists aborted the process.

    The team, made up of members of the Salk Institute in the United States and the Murcia Catholic University, genetically modified the monkey embryos.

    Researchers deactivates the genes which form organs, and replaced them with human stem cells.

    And it is hoped that one day these hybrid-grown organs will be able to be translated into humans.

    Project collaborator Estrella Núñez hailed the experiment as “very promising”.

    The team have not yet published their findings, but confirmed the hybrid to EL PAIS.

    “We are now trying not only to move forward and continue experimenting with human cells and rodent and pig cells, but also with non-human primates,” Izpisúa said.

    The scientist, from Spain, was responsible for creating the first human pig hybrid in 2017.

    Izpisúa however said his human-monkeys are much better than his human-pigs.

    Team member Pablo Ross said: “The human cells did not take hold. We saw that they contributed very little [to the development of the embryo].

    “It was only one human cell for ever 100,000 pig cells.”

    The scientists have also experimented with creating human birds with rats and mice, with the hope to developing transplantable hearts, eyes and pancreases.

    Doctor Ángel Raya, the director of the Barcelona Regenerative Medicine Center, admitted the hybrid experiments do have “ethical barriers”.

    He said: “What happens if the stem cells escape and form human neurons in the brain of the animal?

    “Would it have consciousness? And what happens if these stem cells turn into sperm cells?”

    Núñez has said however if any of the stem cells begin to form a human brain, they will “self destruct”.

    Raya added that the embryos have a “red line” at 14 days of gestation.

    This means that the embryo cannot develop a human central nervous system.

    Scientists then destroys the embryos, and “in no case is the gestation brought to full term”.

    The experiments cost “hundreds of thousands of euros”, Núñez added.

    Núñez downplayed the fact that the university behind the research has a “catholic” moniker.

    She said: “We are doing the experiments with monkeys in China because, in principle, they cannot be done [in Spain].

    “What we want is to make progress for the sake of people who have a disease.

    “The ultimate goal would be to create a human organ that could be transplanted.”
    https://www.dailystar.co.uk/news/wor...nts-scientists



    I don't like this news of a monkey-human hybrid. I didn't know about a pig-human hybrid until I read this article.

    I would refuse an organ transplant grown this way.

    What are your thoughts on this?

    Would you accept a transplanted organ from an animal-human hybrid?

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    They've done it before in secret but they made it public only now. Like George H.W. Bush was probably already snorting coke and banging genetically engineered human-chimp hybrids in deep underground military bases in the 80s.

    Also I don't know if it's true, but Gordon Gallup, who is an evolutionary psychologist who is known for developing the mirror test, says that according to his former university professor, a female chimpanzee and a male human produced a live hybrid offspring in the 1920s (https://www.thesun.co.uk/news/544715...lled-humanzee/):

    Evolutionary psychologist Gordon Gallup coined the term "humanzee" which refers to a human-chimp crossbreed – a scientifically possible hybridisation which was attempted throughout the 20th century.

    Gallup, who developed the famous mirror "self-recognition" test which proved primates could acknowledge their own reflection, claims his former university professor told him that a humanzee baby was born at a research facility where he used to work.

    Speaking to The Sun Online, he said: "One of the most interesting cases involved an attempt which was made back in the 1920s in what was the first primate research centre established in the US in Orange Park, Florida.

    "They inseminated a female chimpanzee with human semen from an undisclosed donor and claimed not only that pregnancy occurred but the pregnancy went full term and resulted in a live birth.

    "But in the matter of days, or a few weeks, they began to consider the moral and ethical considerations and the infant was euthanised."

    Gallup said the professor worked at Yerkes before the research centre moved to Emory University in Atlanta, Georgia in 1930.

    He added: "He told me the rumour was true. And he was a credible scientist in his own right."

    [...]

    And Gallup, who teaches biopsychology at the University at Albany in New York, insists that humans can be crossbred with all the great apes – not just chimpanzees.

    He said: "All of the available evidence both fossil, paleontological and biochemical, including DNA itself, suggests that humans can also breed with gorillas and orangutans."

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    The future is growing organs directly in vitro, not some weird hybrid. However I cannot really understand what they actually did, based on the article (yes I can read exactly the same you can) because I assume it had the same purpose as the in vitro growing, though it's difficult to gather from the article. Would they like to have a whole creature but with a human organs inside? Or is this also some kind of in vitro thingy, because a monkey is smaller than a human. Not sure how this scenario works out. Could also just be a way to start an organ growing in vitro, in which case there doesn't need to be a creature - though maybe there needs to be an embryo to kickstart the organs?
    Last edited by JaM; 2019-08-01 at 22:24.

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    Didn't China make a human pig hybrid some years back,ahh yes they did.Scary I don't approve of this at all.


    First human-pig 'chimera' created in milestone study


    This article is more than 2 years old
    Prospect of growing human organs for transplantation raised by creation of first ever embryos combining two large, distantly related species

    Scientists have created a human-pig hybrid in a milestone study that raises the prospect of being able to grow human organs inside animals for use in transplants.

    It marks the first time that embryos combining two large, distantly-related species have been produced. The creation of this so-called chimera – named after the cross-species beast of Greek mythology – has been hailed as a significant first step towards generating human hearts, livers and kidneys from scratch.

    Human-pig embryos Q&A: how would 'chimeras' make transplant organs?
    Read more
    Juan Carlos Izpisua Belmonte, who led the work on the part-pig, part-human embryos at the Salk Institute for Biological Studies in La Jolla, California, said: “The ultimate goal is to grow functional and transplantable tissue or organs, but we are far away from that. This is an important first step.”

    The study has reignited ethical concerns that have threatened to overshadow the field’s clinical promise. The work inevitably raises the spectre of intelligent animals with humanised brains and also the potential for bizarre hybrid creatures to be accidentally released into the wild. The US National Institutes of Health (NIH) placed a moratorium on funding for the controversial experiments last year while these risks were considered.

    Izpisua Belmonte said that fears around chimeras were inspired largely by mythology rather than the realities of meticulously controlled experiments. But he acknowledged: “The idea of having an animal being born composing of human cells creates some feelings that need to be addressed.”


    The paper, published in the journal Cell, outlines how human stem cells were injected into early-stage pig embryos, resulting in more than 2,000 hybrids that were transferred to surrogate sows. More than 150 of the embryos developed into chimeras that were mostly pig, but with a tiny human contribution of around one in 10,000 cells.

    The pig-human embryos were allowed to develop to 28 days (the first trimester of a pig pregnancy) before being removed.

    “This is long enough for us to try to understand how the human and pig cells mix together early on without raising ethical concerns about mature chimeric animals,” said Izpisua Belmonte.

    The team believe that in future the approach could pave the way for incubating human organs, genetically matched to a patient, for use in transplants or for testing new medicines more safely and effectively.

    Professor Daniel Garry, a cardiologist and head of a different chimera project at the University of Minnesota, said: “This is a significant advance that raises opportunities and ethical questions as well.”


    Human-pig chimeras and the history of transplanting from animals
    Read more
    Garry said that the rapid progress in chimera research had prompted a range of troubling questions, including whether the progeny would look more human or more pig, what would happen if a chimera had a human thought and whether it was possible for the human cells to cannibalise the pig embryo, resulting in a mostly-human, slightly-pig offspring.

    “These more fantastical possibilities are not a problem in reality,” he said, adding that Izpisua Belmonte’s group had taken a “responsible approach”.

    Scientists created the first rat-mouse chimeras a decade ago, but until now have struggled to combine human cells with those of a large mammal.

    Professor Bruce Whitelaw, interim director of the Roslin Institute at the University of Edinburgh, where was created, said: “The 10 years between these two studies is a testament of how difficult it has been to achieve the human-pig result.”

    One challenge is that the pig pregnancy lasts about 112 days, compared to nine months in humans, meaning that the embryonic cells are developing at completely different rates. Izpisua Belmonte’s team found that the human stem cells need to be injected at exactly the right stage in their own development for them to survive and become part of the growing animal – although even then, the efficiency was low.

    Jun Wu, the paper’s lead author and a scientist at Salk, said: “It’s like if you’re going onto a highway where the cars are travelling three times faster than you are, you need to choose the right timing, otherwise you cause an accident.”

    The team is hoping to boost the human contribution by switching off specific genes in the pig embryos that would prevent the pig cells from contributing to target organs, such as the heart, potentially giving the human cells a competitive advantage.


    'Chimera' monkeys created in lab by combining several embryos into one
    Read more
    Similarly, the human cells could be engineered to prevent them contributing to the chimera brain. This safeguard was not in place in the current study, since the embryos were only allowed to reach an early stage of development and the human contribution was minimal.

    “We didn’t see any human cells in the brain region, but we cannot exclude the possibility that they may have gone to the brain,” said Izpisua Belmonte.

    In a separate experiment, the team also created a host of mouse-rat chimeras and showed that rat cells could develop into a gall bladder – even though rats stopped developing this organ themselves at some point in the 18 million years since rats and mice separated evolutionarily.

    This reveals that our genetic code retains the instructions to turn our cells into ancestral forms that have been lost over the course of evolution, raising the intriguing question of which ancient traits might be unlocked from human DNA.

    “Many animals have this extraordinary ability to regenerate,” said Izpisua Belmonte. “Humans don’t have that. [This field of work] could provide a platform for human cells to do that.”

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    Last edited by Menelik; 2019-08-02 at 00:16.

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    I just read that Japanese scientists are planning on making human-rat hybrids!

    I think this is so wrong.


    Rat-human hybrids planned by scientists in chilling glance into the future
    Boffins plan to grow rat-human and mouse-human embryos in Japan.

    The Japanese Research group has received approval from the government to insert human cells into animal embryos.

    After being inserted into the animals, the cells may then grow into organs.

    If research goes well, experts plan on introducing the embryos into other animals such as pigs.

    Ronald Parchem, an assistant professor of neuroscience at Baylor College of Medicine in Houston, said: “I personally thought it was very exciting.

    “It has tremendous potential to help many people who are suffering from a broad variety of diseases or in need of different types of tissue or organ replacement.”

    Japan made headlines when it allowed growing human cells in animal embryos.

    This has allowed a number of experiments to take place, with researchers even planning a human-monkey hybrid.

    Parchem told Live Science: “We don’t actually know what’s going to happen.

    “Our training suggests it’s very unlikely you would get a mouse with human qualities.

    “What you might find is there’s more folding in the brain or there’s more of a certain type of neurotransmitter.”

    It is hoped that organs grown in the species could one day be used for humans.

    He added: “Anytime you take a species and mix it with another, the host species generally does better.

    “If you take a rat cell and put it into a mouse blastocyst, the rat cells are at a disadvantage. That’s why in general, chimerism is very low.”

    Once the hybrid embryos develop, they will be monitored for one to two years.
    https://www.dailystar.co.uk/news/wor...pan-experiment

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    We have become God.
    Quote Originally Posted by Paul Essien View Post
    • The Grimaldi African occupied Europe in ancient times.
    • The original Celtic priesthood were Blacks.
    • Black people constructed Stonehenge.
    • The Scots are themselves of Black origin.
    • The Irish are of black origin.
    • The Knights of King Arthur's round table were Blacks.
    • There was an African, Gormund who ruled Ireland at the time of the Anglo-Saxons.
    • The first King to unite Norway was Black. He was known as Halfdan the Black.
    http://i.imgur.com/uSkUyji.jpg

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    Quote Originally Posted by MnM View Post
    We have become God.
    I think it is evil. It's anti-God.
    I'm against doing experiments on animals and am against splicing/grafting human genes, or however they call it. Human life is special.

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    This is creepy as fuck.

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    China is getting stronger and richer, while not moving at all closer to a constitutional government. The Chinese Communist Party has got “over the hump” into a plateau of stability that, without some severe environmental catastrophe , will probably last for decades. Rich and confident, unrestrained by electoral considerations or Judeo-Christian ethics, or any other kind of ethics, the Chinese will do all the things we dare not do: human genetic experimentation, human-animal hybrids, the killing of “useless mouths,” militarization of space, minor wars of aggression.



    CHINESE

    Racial Characteristics:

    Hordes of incomprehensible rat-eaters with a peculiar political philosophy and a dangerous
    penchant for narcotic drugs. No one can possibly know what dark and grotesque things pass
    through the minds of this hydraheaded racial anomaly which is, after all, more like a monstrous
    colony of flesh-crazed carpenter ants than a nation of rational men. Only a fool would deal with
    two-legged insects ..such as these. Our only hope is that the farsighted leaders of our own land
    Will join with those of at least nominally Caucasian Soviet Russia and that together they will
    treat us to the welcome spectacle of a thermonuclear obliteration of this yellow menace.

    Good Points:

    They're almost as far away as it's possible to be.

    Proper Forms of Address:

    Zipper head, Chink, slant, ching-chong Chinaman, yellow peril.



    An Anecdote Illustrating Something of the Chinese Character:

    Nine hundred million Chinese walk into a bar. They order a beer, pay up, and then just sit there,
    sipping their drinks, not saying a word. Finally, the bartender can't stand it anymore. "We don't
    see many Chinese in here," he says.

    "And with this atmosphere of hedonistic individualism capitalistically exploiting the labor of
    the masses and wasting the people's agricultural resources," say the Chinese, "you won't see
    many more."
    Last edited by DracoSentien; 2019-08-02 at 23:58.
    Eurogenes K15 on steroids via DIYdodecad and more samples etc... via Admixture Studio v1.4 :

    Using 1 populations approximation
    1 100% Southwest_English @ 4.152

    Mix-mode :
    1 75.59% Orcadian + 24.41% East_German @ 2.375 ; Orcadian is NorthEast Scottish e.g. Celtic + Viking

    Using 4 populations approximation
    1 25% East_German + 25% Hinxton3 (ancient England) + 25% Orcadian + 25% Southwest_English @ 2.246

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    That's disgusting. Why would anyone want to do something like that?
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    “A wise man makes his own decisions; an ignorant man follows public opinion.” ― Chinese proverb

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    “Damnant quod non intelligunt.” ― Latin proverb

    Quoted for truth:
    Quote Originally Posted by Alaron View Post
    Anatolian Urhemait supporters are mostly butthurt Meds.
    For the lulz:
    Quote Originally Posted by drgs View Post
    Poland is a misunderstanding. It is a country which lies on the frontier between western and slavic world, and which combines elements of both.
    In fact, they are not even the Europeans in strict sense, meaning European as in bearing the responsibility and understanding of European interests. Poland has always been an subordinate country, on one side sucking German dick, on the other side -- Russian one, some kind of "novice" europeans, who are full of inferiority complexes, hysteria and obsessity neuroses. This is also true for all Baltic countries

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